Few human/machine interfaces are more varied, more ubiquitous or more important than the interaction with keyboards and mice. Keyboard and mice designs are increasingly more varied and may present a difficult decision to industrial hygienists who have to recommend specific devices as part of a computer workstation ergonomics evaluation. Equally critical as the selection of the keyboard and/or mouse is the placement of these devices in the work space of the user. The placement of keyboard and mouse becomes more difficult as computers are used in many different work areas and under varied work conditions. It is important to understand the way relevant characteristics of the devices match with the characteristics of the computer users. This roundtable presents insight on the various design options available in the marketplace, the placement of the devices in context with the work being performed, and software applications that are useful for people to identify and address ergonomic issues within their own workplaces.