Many human cancers originate from misregulation of transcription and altered chromatin structure. In this session, we will explore the mechanisms of transcriptional control and histone modification via histone acetylation, methylation, and chromatin remodeling complexes that are often targeted by tumor suppressors and oncogenes in cancer signaling pathways. This session will highlight different strategies and approaches to defining global and gene-specific regulation in cancer cells, including, for example, the role of chromatin modifying agents in the Wnt/beta-catenin signaling pathway that is disrupted in human colon cancer and melanomas.


Symposium: Transcription and Histone Modification in Cancer

Analysis of Drosophila protein complexes that modify chromatin ; Jerry L. Workman. Stowers Institute for Medical Research, Kansas City, MO

Chromatin modifications at human enhancers reflect global cell type specific gene expression; Bing Ren. University of California, San Diego, La Jolla, CA

Epigenetic regulation of aging and cancer; Jessica K. Tyler. University of Colorado Health Sciences Center, Denver, CO

E2F1 represses beta-cateninin-dependent transcription, and it's activity is antagonized by pRB and cdk8; Nicholas Dyson. Massachusetts General Hospital, Charlestown, MA,