The detailed analysis of the cancer genome has started to yield surprising insights into the pathogenesis of a wide spectrum of different cancers. In this symposium, you will hear from some of the leading investigators in the field of cancer genomics. Their talks will look at a range of different cancers and will describe results from analyses of somatic copy number alterations, genomic rearrangements, and sequence mutations, with the latter ranging from candidate genes, to the coding region of all annotated genes, and ultimately to the analysis of the whole genome. In addition, approaches to differentiate "driver" from "passenger" mutations through the integration of genomic data with expression data and function studies will be described.
Symposium: The Cancer Genome: Recent Advances

The molecular genetics of acute leukemia; James R. Downing. St. Jude Children's Research Hospital, Memphis, TN

Functionalizing the cancer genome; Lynda Chin. Dana-Farber Cancer Inst., Boston, MA

Insights into glioma pathogenesis achieved through genomic analysis of glioblastoma multiforme; Donald W. Parsons. Baylor College of Medicine, Houston, TX

Transforming the cancer genomics paradigm; Elaine Mardis. Washington University School of Medicine, Saint Louis, MO,