Inducible and transient activation of the NF-?B signaling pathway is indispensable for normal immune function and for cellular responses to stress. This session will highlight how cancer often subverts the normal function of the NF-?B pathway. Cancer cells can accumulate genetic alterations in key regulators of the pathway, leading to constitutive activation of the pathway. Chronic inflammation can promote and sustain cancer in part by NF-?B pathway activation in the tumor microenvironment. A detailed understanding of the biochemistry of NF-?B signaling has revealed many steps that are amenable to therapeutic attack.
Symposium: NF-κB in the Development and Maintenance of Cancer

Regulation of NF-κB by deugiquitinases; Vishva M. Dixit. Genentech, Inc., South San Francisco, CA

Critical role of NF-κB activation in normal plasma cells and in multiple myeloma; W. Michael Kuehl. National Naval Medical Center, Bethesda, MD

Re-educating tumor-associated macrophages by targeting NF-κB; Toby Lawrence. Barts and The London School of Medicine and Dentistry, London, United Kingdom

Mechanisms of constitutive NF-κB activation in lymphoma revealed by functional genomics and cancer gene resequencing; Louis M. Staudt. National Cancer Institute, Bethesda, MD,