Upon the sensation of metabolic stress, cancer cells execute a program whereby energy consumption is limited and energy production is enhanced, particularly through glycolysis. This metabolic adaptation is known as the Warburg Effect. How oncogenes and tumor suppressor genes influence these metabolic changes is unknown, and it is unclear whether fatty acid oxidation may contribute. This symposium brings together four leading investigators to report on their latest findings.
Symposium: Cancer Metabolism: Back to the Future

Regulation of cancer cell survival under metabolic stress; Tak W. Mak. University of Toronto, Toronto, ON, Canada

Dual control of caspase-2 by metabolism and the cell cycle machinery; Sally A. Kornbluth. Duke Univ. Medical Center, Durham, NC

The role of myc in cancer metabolism in tumorigenesis; Chi Van Dang. Johns Hopkins Univ. School of Medicine, Baltimore, MD

Cancer cell addiction to glutamine; Craig B. Thompson. University of Pennsylvania, Philadelphia, PA,