AACR 100th Annual Meeting 2009
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(CD-ROM) Set of Audio MP3 Recordings from the AACR 100th Annual MeetingSession ID: CR09-000c Product Type: Physical Disc
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$499.95
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Cell Cycle and Senescence in CancerSession ID: CR09-257 Product Type: Downloadable Uncontrolled cell proliferation is key to cancer development and a number of tumor suppressor proteins function to negatively regulate cell cycle progression, either transiently or through a permanent cell cycle arrest known as cellular senescence. Loss ... Learn More |
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Genome-Wide Association Studies in Cancer: Current and Future DirectionsSession ID: CR09-258 Product Type: Downloadable Genome-wide association studies (GWAS) in cancer have discovered over 50 novel regions of the genome strongly associated with risk for one or more cancers. To date, most published studies have reported on etiologic associations for common cancers (e.g., b... Learn More |
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Imaging Cancer Invasion: Metastasis and ResistanceSession ID: CR09-259 Product Type: Downloadable Dynamic imaging has greatly enhanced our mechanistic insight into cancer progression and metastasis as well as the host response to the lesion. Addressing cancer dynamics in the context of the tumor microenvironment, 3D tissue culture and intravital micro... Learn More |
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NF-kB in the Development and Maintenance of CancerSession ID: CR09-260 Product Type: Downloadable Inducible and transient activation of the NF-?B signaling pathway is indispensable for normal immune function and for cellular responses to stress. This session will highlight how cancer often subverts the normal function of the NF-?B pathway. Cancer ce... Learn More |
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The Cancer Genome: Recent AdvancesSession ID: CR09-261 Product Type: Downloadable The detailed analysis of the cancer genome has started to yield surprising insights into the pathogenesis of a wide spectrum of different cancers. In this symposium, you will hear from some of the leading investigators in the field of cancer genomics. The... Learn More |
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From Molecular Tumor Markers to Health Behaviors: Promises and Challenges of Cancer SurvivorshipSession ID: CR09-262 Product Type: Downloadable With the advent of new treatment modalities, the number of cancer survivors continues to increase. More than 10 million cancer survivors in the United States challenge researchers to address issues related to tailoring of therapies and research on cancer... Learn More |
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Autophagy, Metabolic Stress, and Therapeutic ResponseSession ID: CR09-263 Product Type: Downloadable Autophagy is a cellular response to starvation and stress where cells form vesicles called autophagosomes that capture cellular components including organelles, protein aggregates and cytoplasm, which then fuse with lysosomes and are degraded. This lysos... Learn More |
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Cancer Therapeutics and NanotechnologySession ID: CR09-264 Product Type: Downloadable With recent support and encouragement from the National Cancer Institute, biologists, engineers, chemists and physicians have been brought together to develop innovative nanotechnology platforms for cancer detection and therapy. Advances in nanoparticle ... Learn More |
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(Download) Set of Audio MP3 Recordings from the AACR 100th Annual MeetingSession ID: CR09-000d Product Type: Downloadable
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$499.95
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Cancer Metabolism: Back to the FutureSession ID: CR09-256 Product Type: Downloadable Upon the sensation of metabolic stress, cancer cells execute a program whereby energy consumption is limited and energy production is enhanced, particularly through glycolysis. This metabolic adaptation is known as the Warburg Effect. How oncogenes and tu... Learn More |
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The Bayard D. Clarkson Symposium on Stem Cells and Cancer: Advances in Cancer Stem CellsSession ID: CR09-255 Product Type: Downloadable Cancers are aberrant organ systems that display a hierarchy of neoplastic cells including cells that are capable of sustained self renewal and tumor propagation. These cancer stem cells are relatively resistant to radiation and chemotherapy, promote angi... Learn More |
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AACR/ASCO Symposium: COX-2 and Cancer TreatmentSession ID: CR09-254 Product Type: Downloadable Cyclooxygenase-2 (COX-2) has been recognized as a potential target for cancer chemoprevention and, indeed, several prospective randomized clinical trials have demonstrated the effectiveness of celecoxib, a selective COX-2 inhibitor, in preventing formatio... Learn More |
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Transcription and Histone Modification in CancerSession ID: CR09-245 Product Type: Downloadable Many human cancers originate from misregulation of transcription and altered chromatin structure. In this session, we will explore the mechanisms of transcriptional control and histone modification via histone acetylation, methylation, and chromatin remo... Learn More |
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Ethical Issues in PublicationsSession ID: CR09-246 Product Type: Downloadable For the past several years the AACR has established a tradition of discussing contemporary ethical issues in cancer research. Continuing in this tradition we will explore at the 2009 annual meeting some of the many ethical problems that arise when studie... Learn More |
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Circulating Tumor Cells: Biology and Clinical Applications for Research and PracticeSession ID: CR09-247 Product Type: Downloadable The dissemination of tumor cells into the circulation is a necessary but not sufficient step in the metastatic process. Recent trials using an FDA cleared assay, show that circulating tumor cell number is a biomarker of prognosis, which is currently unde... Learn More |
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Cancer Genomics and Drug DiscoverySession ID: CR09-248 Product Type: Downloadable
This session will focus on the use of genetic tools to identify novel targets for therapy and the discovery of biomarkers that can be used to predict responses to therapy in the clinic. |
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Epithelial-Mesenchymal Transitions in CancerSession ID: CR09-249 Product Type: Downloadable Epithelial to mesenchymal transition (EMT), an important developmental process, is believed to play a pivotal role in the metastatic dissemination of epithelial tumor cells. The mechanisms that regulate EMT and the functional consequences of EMT in devel... Learn More |
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How Do Mouse Models of Cancer Inform Clinical Trials?Session ID: CR09-250 Product Type: Downloadable Genetically engineered mouse models (GEMM) of cancer have provided numerous insights into the molecular pathways and processes that contribute to the normal control of cell growth and differentiation in many different organ systems. GEMM allow the analys... Learn More |
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Immune Regulation in the Tumor MicroenvironmentSession ID: CR09-251 Product Type: Downloadable Although tumor antigens are expressed by the majority of cancers, and T cells can be generated than can kill antigen-expressing tumor cells in vitro, T cell-based immunotherapies in the clinic have yielded only modest success. Active immunization and ado... Learn More |
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Molecular Biomarkers of Response and ToxicitySession ID: CR09-252 Product Type: Downloadable This session will focus on discussions regarding the utilization of molecular biomarkers for evaluation of drug target effect and toxicity. As the focus of many novel drugs is now tumor target effects the drug development community is faced with the chall... Learn More |
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Ruth Sager Memorial Symposium on Cancer Genetics and Epigenetics: Epigenomics and the Stem Cell: The Cancer ConnectionSession ID: CR09-253 Product Type: Downloadable Recent developments in whole epigenomic analysis have led to an explosion of knowledge of the links between chromatin structure and stem cell behavior and differentiation. Importantly, chromatin structures established in embryonic stem cells alter the pre... Learn More |
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Cancer Systems Biology: Fact or Fiction?Session ID: CR09-171 Product Type: Downloadable Experimental and computational approaches now abound for large scale analysis of normal and malignant tissues in humans and in model systems. This forum will focus on progress and problems in moving from large scale descriptions of these complex systems... Learn More |
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New Views on Mammographic DensitySession ID: CR09-172 Product Type: Downloadable Breast density assessed from clinical mammograms remains one of the strongest breast cancer risk factors. Volumetric measures offer a "new view" of breast density providing an assessment of dense volume rather than dense area. Since volumetric density ... Learn More |
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Emerging Biological Observations in Prostate Cancer and Their TranslationSession ID: CR09-173 Product Type: Downloadable Despite recent advances in its diagnosis and treatment, prostate cancer remains a major cause of cancer death. The dire outcome for men diagnosed with advanced prostate cancer, and particularly castration-resistant disease, warrants focused analyses linki... Learn More |
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Genetic Basis of Childhood CancerSession ID: CR09-174 Product Type: Downloadable Many of the seminal discoveries in the field of cancer genetics have been made in relatively rare malignancies arising during childhood. These discoveries have dramatically enhanced our understanding of cancer initiation and progression, but as of yet hav... Learn More |
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Invading the Sanctuary: New Approaches to Brain MetastasesSession ID: CR09-175 Product Type: Downloadable Molecular pathways regulate tumor metastasis generally or in a site specific manner. Brain metastases are widespread but most prevalent in lung and breast cancers, and melanoma. They are increasing in incidence as a "sanctuary" site as systemic therapy im... Learn More |
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State-of-the-Art Pathophysiology and Therapy of Acute Myeloid LeukemiaSession ID: CR09-176 Product Type: Downloadable Despite significant advances in the therapy of acute myeloid leukemia (AML) the cure rate in adults with AML is only 25% to 40%. In the last few years, major progress has been made in the understanding of the biology of this disease. The discovery of a n... Learn More |
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Cancer Stem Cells: Advances and ChallengesSession ID: CR09-170 Product Type: Downloadable Recent findings, first in leukemia and then in solid cancer, that only a fraction of the cells in a cancer tissue are capable of initiating and maintaining cancer growth have led to an intense focus on the stem cell nature of cancer. Expectations are tha... Learn More |
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Targeting the RB Pathway in Cancer TherapySession ID: CR09-169 Product Type: Downloadable Genetic and epigenetic alterations in the RB pathway" are common among human cancers. Through mutational events or gene silencing mechanisms cancer cells either eliminate the Rb gene or hyper-activate RB phosphorylation to neutralize its tumor suppressio... Learn More |
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Prostate Cancer: Latent versus Clinically Significant Disease: Does Every Cancer Need Intervention?Session ID: CR09-168 Product Type: Downloadable Prostate Cancer is a considerable health risk for men throughout the world. Screening with PSA has led to an increasing number of patients diagnosed with small volume, low grade cancer. Since many of this cancers grow slowly and, even if untreated, never ... Learn More |
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Exploiting the Hypoxic Tumor Microenvironment for TherapeuticsSession ID: CR09-167 Product Type: Downloadable In this forum the role of hypoxia as a potential target for cancer therapeutics will be discussed. Changes in oxygen levels within solid tumors profoundly affect the biological behavior of cancer cells and their response to therapy. However, an apparent s... Learn More |
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A New Paradigm for Understanding Excess Cancer Risk in Underserved and Minority Populations: The Centers for Population Health and Health Disparities ExperienceSession ID: CR09-166 Product Type: Downloadable Over the last 5 years the NIH-funded Centers for Population Health and Health Disparities have used transdisciplinary science within a multi-level framework to understand and address cancer health disparities in underserved and minority populations across... Learn More |
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Impact of the New Administration's Priorities on Cancer ResearchSession ID: CR09-165 Product Type: Downloadable How will the Obama Administration and the new Congress affect your research? Significant changes to our health care system have been promised and pledges to support research could positively impact NIH and NCI. New policies for health care, economic stimu... Learn More |
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Therapeutic Targets and Breast Cancer Stem CellsSession ID: CR09-164 Product Type: Downloadable There is increasing preclinical and clinical evidence that breast cancer stem cells are relatively resistant to both radiation and chemotherapy thereby contributing to treatment resistance and relapse. This suggests that improved clinical outcomes may req... Learn More |
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Targeting EGFR in Lung CancerSession ID: CR09-163 Product Type: Downloadable A majority of human epithelial cancers including treatment of non-small cell lung cancer are marked by functional activation of growth factors and receptors of the epidermal growth factor receptor (EGFR) family. After nearly two decades of drug developmen... Learn More |
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Tumor-Stromal Interactions Regulating Breast Tumor ProgressionSession ID: CR09-177 Product Type: Downloadable The tumor microenvironment plays important roles in cancer initiation and progression, yet the molecular mechanisms underlying these tumor-promoting effects are only beginning to be understood. Recent studies analyzing the gene expression, genetic, and ep... Learn More |
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Basic and Translational Advances in Pancreatic Cancer TreatmentSession ID: CR09-178 Product Type: Downloadable There are currently few effective therapeutic options for patients with pancreatic cancer. New insights into the pathogenesis of this disease are desperately needed to provide more effective treatment options for these patients. This session will address ... Learn More |
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From Experimental Models to Targeted Therapy of Neuroendocrine TumorsSession ID: CR09-179 Product Type: Downloadable Neuroendocrine tumors are the spectrum of tumors that range from well- to poorly-differentiated histology as well as indolent to aggressive behavior clinically. In this session, we focus on three subtypes of well-differentiated neuroendocrine carcinomas ... Learn More |
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Molecular and Cellular Determinants of Colorectal Cancer MetastasisSession ID: CR09-194 Product Type: Downloadable The majority of colorectal cancer (CRC) research focuses on tumor initiation and progression, with relatively little work being done in the field of processes that lead to metastasis and the role of the organ microenvironment on enhancing metastatic tumor... Learn More |
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Malignant Progression in Myelodysplastic Syndrome: Back to the BenchSession ID: CR09-193 Product Type: Downloadable Until recently, the molecular pathophysiology of myelodysplastic syndrome (MDS) was very poorly understood. No cell or animal model of the disease existed, and therapeutic options were largely limited to supportive care or bone marrow transplantation. Re... Learn More |
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Recent Advances in Hepatocellular Cancer: From Molecular Profiling to TherapeuticsSession ID: CR09-192 Product Type: Downloadable The incidence of hepatocellular carcinoma (HCC) is rising in the United States and it is projected to continue to increase over the next decade. This session will highlight recent advances in research in hepatocellular cancer and will include speakers o... Learn More |
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Pancreatic Cancer Genomics: Prospects for Prediction and TherapySession ID: CR09-191 Product Type: Downloadable New developments in genomic technology are being used in better understanding the genetic and molecular basis of pancreatic cancer. Cutting edge discoveries using cell lines, tissues, and large patient series have illuminated our understanding of the bio... Learn More |
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Inflammatory Breast Cancer: A Global Perspective of Translation from the Laboratory to the ClinicSession ID: CR09-189 Product Type: Downloadable This symposium will focus on the definition, epidemiology, molecular determinants, and animal models of inflammatory breast cancer, all approached from the perspective of how can this knowledge be best put to use for the benefit of the patient. The co-ch... Learn More |
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Human Papillomavirus and Head and Neck CancerSession ID: CR09-188 Product Type: Downloadable The incidence of human Papilloma virus (HPV)-related head and neck cancer (HNC) has been increasing in the United States and Europe. The disease generally occurs in younger non-smoking population with distinct pathology and clinical outcome compared to no... Learn More |
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The Molecular Biology of Lung Cancer in Never Smokers: A Different DiseaseSession ID: CR09-187 Product Type: Downloadable Lung cancer in never smokers or light smokers represents a clinically and biological distinct disease from that in smokers, but also has unacceptably poor outcomes. This assertion has been supported by retrospective studies showing differences in surviva... Learn More |
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Molecularly Targeted Therapy in Melanoma: Promise and PitfallsSession ID: CR09-185 Product Type: Downloadable When considered at a per-cell level, malignant melanoma represents one of the most deadly human solid tumors. Pivotal discoveries-- such as the finding of BRAF mutations in more than 50% of cutaneous melanomas and KIT mutations in acral and mucosal melano... Learn More |
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Molecular Epidemiology of Rare Tumors: Challenges and OpportunitiesSession ID: CR09-184 Product Type: Downloadable The study of rare cancers has provided considerable insight into the genetic and environmental basis of carcinogenesis (e.g., retinoblastoma and the "two-hit" model, diethylstilbestrol and vaginal clear cell carcinoma, aflatoxin and hepatocellular carcino... Learn More |
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Colon Cancer: Biology, Genetics, and Early DetectionSession ID: CR09-183 Product Type: Downloadable Colorectal cancers represent one of the most commonly diagnosed human cancer types, affecting nearly 1 million individuals world-wide each year. The identification of hereditary and somatic genetic alterations in colorectal cancers has provided a basis f... Learn More |
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Triple Negative Breast Cancer: Molecular Profiles, Mechanisms, and Clinical DirectionsSession ID: CR09-182 Product Type: Downloadable Triple-negative breast cancers are negative for estrogen and progesterone receptor expression and HER2 gene amplification. About 80% have a basal-like gene expression profile and, overall, they exhibit a poor prognosis and a low response to commonly used ... Learn More |
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